Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 (methylcobalamin) is used in the context of Multiple Sclerosis (MS) largely due to its critical role in neurological function and myelin synthesis. There is some scientific rationale for its use: Vitamin B12 deficiency can result in neurological symptoms similar to those seen in MS, including demyelination and neuropathy. Several case reports and small observational studies have documented patients with MS who also have low or borderline B12 levels, leading to recommendations that MS patients should be screened for deficiency and supplemented if necessary.

However, clinical trials specifically testing Vitamin B12 supplementation in patients with adequate B12 levels have not demonstrated clear benefit in slowing MS progression or improving symptoms. A few small studies and anecdotal reports suggest possible symptomatic improvement, but these findings have not been consistently replicated in larger, controlled trials. As a result, major neurology guidelines do not currently recommend B12 supplementation for MS patients unless deficiency is present.

In summary, the use of Vitamin B12 in MS is scientifically justified only for correcting deficiency; there is not strong evidence that supplementation benefits MS patients who have normal B12 levels. The evidence for benefit in this context is limited (rated 2/5), mainly based on mechanistic plausibility and case reports rather than robust clinical trials.

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