Evidence supporting the use of: Phenylpiracetam
For the health condition: Multiple Sclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phenylpiracetam (also known as fonturacetam or Carphedon) has been studied as a potential adjunct treatment in Multiple Sclerosis (MS), primarily due to its purported neuroprotective, cognitive-enhancing, and psychostimulant effects. Some clinical trials, mainly from Russia where the compound was developed and approved for medical use, have reported that phenylpiracetam may help reduce certain MS symptoms, particularly fatigue, cognitive impairment, and motor dysfunction. For example, small-scale studies have suggested improvements in physical endurance and cognitive performance in patients with MS-related fatigue. The proposed mechanisms include enhanced neuronal metabolism, increased resistance of brain tissue to hypoxia, and modulation of neurotransmitter systems.

However, the quality and quantity of evidence are limited. Most studies are small, not widely replicated, and many are published only in Russian-language journals, making independent verification difficult. Phenylpiracetam is not approved for MS treatment in most countries, and it is not included in major international MS treatment guidelines. Thus, while there is some scientific investigation supporting the use of phenylpiracetam for MS-related symptoms, the overall level of evidence is low, and further high-quality, large-scale randomized controlled trials are needed to establish its efficacy and safety in this context.

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Products containing phenylpiracetam

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