Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin is a flavonoid found in many fruits, vegetables, and herbs, and has been studied for its potential neuroprotective and anti-inflammatory effects. Its relevance to Multiple Sclerosis (MS) arises from preclinical research indicating that luteolin can modulate immune responses and reduce neuroinflammation, which are key factors in MS pathology. In vitro and animal studies have demonstrated that luteolin can inhibit the activation of microglia and mast cells, decrease the production of pro-inflammatory cytokines (such as TNF-α and IL-6), and suppress T-cell activation—all processes implicated in the development and progression of MS.

Notably, a few animal model studies (e.g., in experimental autoimmune encephalomyelitis, the standard MS model) have shown that luteolin administration can reduce disease severity and demyelination. However, robust human clinical trials are lacking. Some researchers have proposed luteolin as an adjunctive therapy due to its ability to cross the blood-brain barrier and its relatively favorable safety profile, but its use in MS remains investigational.

In summary, while there is some scientific rationale based on preclinical evidence for luteolin’s potential benefits in MS, clinical efficacy in humans has not been convincingly demonstrated. Thus, the evidence is rated as 2 out of 5, reflecting promising laboratory findings but insufficient clinical validation.

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