Evidence supporting the use of: EGCG
For the health condition: Multiple Sclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG), a polyphenol found in green tea, has been investigated for its potential neuroprotective and anti-inflammatory properties relevant to Multiple Sclerosis (MS). Preclinical studies, particularly in animal models such as Experimental Autoimmune Encephalomyelitis (EAE), have shown that EGCG can modulate immune responses, reduce demyelination, and decrease neuroinflammation. These effects are thought to be mediated by its antioxidant activity, inhibition of pro-inflammatory cytokines, and protection against oxidative stress-induced neuronal damage.

However, human clinical data are limited. A few small-scale clinical trials have examined the safety and potential efficacy of EGCG supplementation in MS patients. For example, a pilot study found that oral EGCG was well-tolerated but did not significantly improve clinical outcomes or MRI parameters over placebo. Another study suggested possible benefits in reducing neurofilament light chain levels (a marker of neuronal damage), but these findings are preliminary and require confirmation.

Overall, while preclinical evidence provides a scientific rationale for exploring EGCG as a supportive treatment in MS, the quality and quantity of clinical evidence remain insufficient to warrant strong recommendations. Thus, the evidence supporting its use is currently modest (rating: 2/5), and larger, well-designed human trials are needed to determine efficacy and safety in MS patients.

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Products containing EGCG

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