Glycyrrhiza, commonly known as licorice root, has a long history of use in traditional medicine systems such as Traditional Chinese Medicine (TCM) and Ayurveda for supporting the health of mucus membranes, particularly within the respiratory and gastrointestinal tracts. Historically, it has been used to soothe sore throats, alleviate coughs, and address gastric irritation, which are all conditions involving the mucus membranes.

Scientific studies have validated several of these traditional uses. The main active component, glycyrrhizin, along with other flavonoids present in Glycyrrhiza, has demonstrated anti-inflammatory, demulcent (soothing), and mucoprotective effects in preclinical and some clinical studies. Research has shown that licorice extracts can increase the secretion of mucus in the stomach, providing a protective effect against ulcers and irritation. Similarly, its anti-inflammatory and antimicrobial properties can help soothe irritated mucosal tissues in the respiratory tract, which supports its use for coughs and sore throats.

While more high-quality clinical trials would further strengthen the evidence, current data support the use of Glycyrrhiza for supporting mucus membrane health. Care must be taken with prolonged use or high doses due to potential side effects such as hypertension and hypokalemia.