Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ceramides are lipid molecules naturally present in cell membranes and are particularly abundant in the skin and mucus membranes, where they play a crucial role in maintaining the barrier function and retaining moisture. Scientific research has shown that ceramides help bolster the protective layers of both the skin and mucosal surfaces, thereby supporting hydration and integrity. In the context of mucus membranes—such as those lining the mouth, respiratory tract, and digestive tract—ceramides contribute to forming a barrier that helps prevent pathogen entry and moisture loss. Clinical studies, primarily in dermatology, have demonstrated that oral and topical ceramide supplementation can improve barrier function and moisture retention. Although direct studies on mucus membranes (as opposed to skin) are fewer, emerging evidence suggests that ceramide supplementation may benefit conditions characterized by mucosal dryness, such as dry mouth (xerostomia). For example, a small number of human studies have reported improved oral moisture levels with oral ceramide supplements. However, the majority of robust, placebo-controlled trials focus on skin health rather than mucosal surfaces, so while the biological rationale is strong, more targeted research is needed to confirm efficacy specifically for mucus membranes. Therefore, the use of ceramides to support mucus membrane health is scientifically plausible and modestly supported by preliminary evidence, but not yet conclusively proven.

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