Evidence supporting the use of: Aloe vera
For the body system: Mucus Membranes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Aloe vera has been traditionally used and scientifically investigated for its effects on mucus membranes, particularly those of the gastrointestinal tract. The inner leaf gel of Aloe vera contains polysaccharides, glycoproteins, and other bioactive compounds believed to have soothing and anti-inflammatory properties. Several studies in both animals and humans have examined Aloe vera’s impact on the mucosal lining of the gut. For example, a randomized, double-blind, placebo-controlled trial (Aliment Pharmacol Ther, 2004) found that oral Aloe vera gel reduced symptoms in patients with ulcerative colitis, a condition characterized by inflammation of the colon’s mucus membrane. In vitro and animal studies have also demonstrated that Aloe vera may promote epithelial healing, stimulate mucus secretion, and modulate inflammation, all of which could support the health of mucus membranes. However, the quality and size of clinical studies are variable, and some meta-analyses and reviews note inconsistent findings, with some studies failing to show significant benefits in humans. Aloe vera is generally regarded as safe when used appropriately, but oral use in large amounts can cause gastrointestinal discomfort or laxative effects due to anthraquinones in the latex portion (which is typically removed in commercial preparations). In summary, there is modest scientific support for Aloe vera’s use in supporting mucus membrane health, but more large-scale, high-quality clinical trials are needed to fully substantiate these effects.

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