Evidence supporting the use of: Vitamin B6
For the health condition: Mood Swings

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) is scientifically studied in relation to mood regulation, particularly for its role in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which are critical for mood balance. Several clinical studies have shown that vitamin B6 supplementation may help reduce symptoms of mood swings, especially in specific populations. For example, randomized controlled trials have demonstrated the benefit of vitamin B6 in alleviating premenstrual syndrome (PMS) symptoms, including mood swings, irritability, and depression. A 2019 systematic review found moderate-quality evidence that vitamin B6 can reduce premenstrual emotional symptoms.

The proposed mechanism is that vitamin B6 acts as a cofactor for enzymes involved in neurotransmitter biosynthesis, thus potentially correcting imbalances that contribute to mood disturbances. While some studies have explored its use in generalized mood disorders and depression, the evidence is less robust outside of PMS and related conditions. The overall quality of evidence is moderate (rated 3/5), with most benefits observed in individuals with either a deficiency or specific hormonal-related mood variations.

In summary, there is scientific support for the use of vitamin B6 in managing mood swings, particularly in PMS, but evidence is mixed or limited for broader mood disorder applications. Supplementation should be approached cautiously and ideally under medical supervision, as excessive vitamin B6 can have adverse effects.

More about vitamin B6
More about Mood Swings

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