Evidence supporting the use of: Lactobacillus casei
For the health condition: Mood Swings

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus casei is a probiotic bacterium commonly found in the human gut and in fermented foods. Its use in supporting or treating mood swings is primarily based on emerging scientific research into the gut-brain axis—the bidirectional communication system between the gut microbiota and the central nervous system. Several preclinical and clinical studies have suggested that alterations in gut bacteria may influence mood, behavior, and mental health. Some small-scale human trials and animal studies have shown that supplementation with L. casei and other probiotics can have beneficial effects on mood, symptoms of depression, and psychological stress. For example, a randomized controlled trial published in the British Journal of Nutrition (2013) found that daily consumption of a probiotic drink containing L. casei improved mood in participants experiencing low mood. The mechanisms proposed include modulation of inflammatory pathways, production of neuroactive compounds (like GABA), and influence on neurotransmitter synthesis. However, the overall body of evidence is modest, with limited sample sizes and variable methodologies. There is some scientific validation for the use of L. casei in supporting mood and potentially reducing mood swings, but the evidence is not strong or conclusive enough to warrant a high rating. Further large-scale, well-designed clinical trials are needed to clarify its efficacy and specific role in mood regulation.

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