Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Endorphins are endogenous neuropeptides produced by the central nervous system and the pituitary gland, primarily known for their role in pain modulation and the generation of feelings of pleasure or euphoria. Scientific research indicates that endorphins may play a role in regulating mood and emotional responses. Fluctuations in endorphin levels have been associated with mood disorders, including depression and mood swings, although the exact mechanisms remain incompletely understood.

Physical activity, laughter, and certain types of social interaction can increase endorphin release, which is thought to contribute to improved mood and emotional stability. Some studies have observed that interventions elevating endorphin levels (such as exercise or acupuncture) can help reduce mood swings, particularly in populations with mood disorders or premenstrual syndrome. However, it is important to note that there is currently no clinical formulation of "endorphin" as a supplement or medication for mood swings; instead, strategies to boost endogenous endorphin production are usually recommended.

Overall, while there is a plausible biological basis and some indirect evidence supporting the role of endorphins in mood regulation, direct supplementation or external administration of endorphins for mood swings is not established in clinical practice. The evidence supporting endorphin-targeted interventions for mood swings is limited and mostly indirect, hence a moderate evidence rating.

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