Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium (mixed) probiotics have received some scientific attention for their potential impact on mood, including mood swings, though the evidence is still preliminary and not robust. Research in the emerging field of the gut-brain axis suggests that gut microbiota may influence mental health through immune, neural, and endocrine pathways. Several small-scale clinical trials and animal studies have explored the use of Bifidobacterium strains (often in combination with other probiotics such as Lactobacillus) for improving mood and reducing symptoms of depression or anxiety. For example, a 2016 randomized controlled trial found that a combination of Bifidobacterium longum and Lactobacillus helveticus modestly improved self-reported mood and reduced psychological distress in healthy volunteers. Another study in 2017 showed that Bifidobacterium longum NCC3001 reduced depression scores in patients with irritable bowel syndrome. However, direct evidence specifically targeting "mood swings" as a clinical entity is limited, and most studies focus on general mood, anxiety, or depressive symptoms rather than episodic mood fluctuations. The overall quality of evidence is low to moderate, with small sample sizes and varying methodologies. In summary, while there is a scientific rationale and some early clinical evidence for Bifidobacterium's impact on mood, its specific effectiveness for treating or supporting mood swings is not well-established, and more high-quality, targeted research is needed.

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