Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Watermelon is sometimes discussed in the context of mitochondrial health due to its content of L-citrulline, a non-essential amino acid. L-citrulline is involved in the urea cycle and has been shown to increase levels of L-arginine and nitric oxide in the body, which can enhance blood flow and potentially improve the delivery of oxygen and nutrients to mitochondria. Additionally, watermelon is a good source of antioxidants such as vitamin C and lycopene, which may help mitigate oxidative stress—a known factor in mitochondrial dysfunction. Some scientific studies suggest that L-citrulline supplementation can improve exercise performance and muscle metabolism, indirectly supporting mitochondrial function. However, direct evidence linking watermelon consumption to enhanced mitochondrial health in humans is limited and mostly extrapolated from studies on its individual components or from animal and in vitro studies. Thus, while there is some scientific rationale and limited preliminary evidence, the support is not robust or conclusive, warranting a modest evidence rating.

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