Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B5 (calcium pantothenate) is an essential nutrient that plays a crucial role in mitochondrial function. It is a precursor for the synthesis of coenzyme A (CoA), a molecule necessary for the metabolism of carbohydrates, fats, and proteins within the mitochondria. CoA is central to the citric acid cycle (Krebs cycle), which is the primary pathway for energy (ATP) production in cells. Deficiency in vitamin B5 can impair energy metabolism and mitochondrial function, as demonstrated in animal studies and case reports of rare human deficiency. However, frank deficiency is very uncommon, and there is limited evidence that supplementation above the recommended dietary allowance provides additional mitochondrial support in healthy individuals.

Experimental studies and biochemical knowledge confirm the necessity of pantothenic acid for mitochondrial energy production. Some preliminary studies have explored its use in fatigue and athletic performance, but results are inconclusive and do not provide strong evidence for supplementation in these contexts. Thus, while there is clear scientific validation for vitamin B5 as a required component for mitochondrial function, the clinical evidence for using supplemental B5 specifically to "support the mitochondria" in otherwise healthy individuals is moderate. This rating reflects the strong biochemical basis but limited evidence for benefit from supplementation beyond addressing deficiency.

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