Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B3, also known as niacin, plays a scientifically validated role in supporting mitochondrial function. Niacin is a precursor to nicotinamide adenine dinucleotide (NAD⁺), a crucial coenzyme involved in redox reactions within the mitochondria. NAD⁺ acts as an essential electron carrier in the mitochondrial electron transport chain, which drives ATP production—the primary energy currency of the cell. Research has shown that supplementation with vitamin B3 or its derivatives (such as nicotinamide riboside or nicotinamide mononucleotide) can increase cellular NAD⁺ levels, thereby enhancing mitochondrial function and biogenesis, especially in aging or metabolically stressed tissues.

Preclinical studies in animal models demonstrate that boosting NAD⁺ with vitamin B3 derivatives improves mitochondrial health, energy metabolism, and resistance to metabolic and age-related diseases. Some early-phase human studies suggest potential benefits for mitochondrial function, muscle performance, and neuroprotection, though larger clinical trials are needed for conclusive evidence. The scientific rationale for using vitamin B3 to support mitochondrial health is well-established mechanistically, but the translation into widespread clinical use is still emerging. Nonetheless, vitamin B3’s fundamental role in mitochondrial energy metabolism justifies its use for supporting this body system.

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