Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B3, which includes niacin (nicotinic acid) and niacinamide (nicotinamide), has scientific validation for supporting mitochondrial function. Both forms of vitamin B3 are precursors to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme found in all living cells. NAD+ is essential for mitochondrial energy metabolism, acting as an electron carrier in the electron transport chain, which drives ATP synthesis—the main source of cellular energy. Research has demonstrated that NAD+ levels decline with age and in various disease states, leading to impaired mitochondrial function. Supplementation with vitamin B3 can increase NAD+ levels, supporting mitochondrial health and energy production. Several studies in animals and humans have shown that niacinamide and other NAD+ precursors can improve mitochondrial function, protect against neurodegeneration, and may ameliorate age-related cellular decline. However, most clinical evidence currently comes from animal models or early-phase human studies, and more research is needed to confirm these effects in larger populations and specific disease contexts. In summary, the use of vitamin B3 to support mitochondrial function is based on well-established biochemical roles and a growing body of scientific evidence.

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