Vitamin B2, also known as riboflavin, is scientifically validated as an essential nutrient for mitochondrial function. Riboflavin is a precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), both of which are crucial for mitochondrial energy metabolism. These coenzymes participate directly in the electron transport chain, a central component of ATP production within mitochondria. Deficiency in riboflavin impairs the function of several flavoproteins required for oxidative phosphorylation, leading to reduced cellular energy output.

Clinical and biochemical studies have shown that riboflavin supplementation can be beneficial for certain mitochondrial disorders, such as multiple acyl-CoA dehydrogenase deficiency (MADD) and some forms of complex I deficiency, where riboflavin-dependent enzymes are dysfunctional. The European Journal of Neurology (2012) and other peer-reviewed sources document the use of riboflavin in the management of mitochondrial myopathies, with improvement observed in some patients.

In summary, the role of Vitamin B2 in mitochondrial health is well established at the biochemical and clinical level, justifying its use to support the mitochondrial body system. The evidence is robust, and riboflavin is considered essential for mitochondrial energy metabolism in both health and disease contexts.