Evidence supporting the use of: Vitamin B1 (mixed)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin B1 (Thiamine) plays a crucial role in mitochondrial function and energy metabolism. Thiamine is an essential cofactor for several mitochondrial enzymes, notably pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, which are key components of the citric acid (Krebs) cycle. These enzymes are responsible for converting carbohydrates into adenosine triphosphate (ATP), the primary energy currency of the cell. Thiamine deficiency impairs these pathways, leading to reduced ATP production and mitochondrial dysfunction. Clinical syndromes such as beriberi and Wernicke-Korsakoff syndrome, both caused by thiamine deficiency, are characterized by symptoms linked to cellular energy deficits, emphasizing thiamine’s importance for mitochondrial health. Several animal and cell culture studies, as well as limited human data, suggest that adequate thiamine supports optimal mitochondrial function and may help mitigate certain mitochondrial diseases or dysfunctions. However, while the biochemical rationale is strong and deficiency states are clearly harmful, there is limited evidence from high-quality clinical trials demonstrating that thiamine supplementation improves mitochondrial function in healthy individuals or in most mitochondrial diseases. Thus, the use of Vitamin B1 to support the mitochondrial body system is scientifically grounded but not universally validated by robust clinical trial data, warranting a moderate evidence rating.
Other ingredients that support Mitochondria
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Flavin mononucleotide
Fish
Fatty acids
Fucoxanthin
Flavones
Ginsenosides
Gamma-Glutamylcysteine
glucose
Glutathione
Geranylgeraniol
Ketone Salts
Other body systems supported by Vitamin B1 (mixed)
BrainCirculatory System
Digestive System
Gastrointestinal Tract
Heart
Immune System
Intestinal System
Liver
Mitochondria
Nerves
Senses
Small Intestines
