Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B complex, which includes vitamins such as B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin), plays a critical role in mitochondrial function. Several B vitamins serve as essential cofactors and coenzymes in mitochondrial energy metabolism, particularly in the processes of glycolysis, the citric acid (Krebs) cycle, and the electron transport chain. For example, thiamine, riboflavin, and niacin are directly involved in enzymatic reactions that generate ATP, the primary energy currency of the cell, within mitochondria. Deficiencies in these vitamins have been associated with impaired mitochondrial function and resulting clinical syndromes, such as lactic acidosis and neuropathies. Clinical research and biochemical evidence both strongly support the importance of adequate B vitamin levels for maintaining healthy mitochondrial energy production. While supplementation is most effective in cases of deficiency or increased metabolic demand, the foundational role of B vitamins in mitochondrial pathways is well-established and widely acknowledged in scientific literature (e.g., PMID: 31280116, 20303848). Thus, the use of B vitamins to support mitochondrial health is scientifically validated.

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