Vegetable and fruit blends are commonly included in dietary supplements marketed for mitochondrial support due to their content of polyphenols, vitamins, minerals, and antioxidants. Several scientific studies have shown that diets high in fruits and vegetables are associated with improved markers of cellular health, including reduced oxidative stress, which is relevant for mitochondrial function. Mitochondria are susceptible to oxidative damage, and antioxidants from plant sources (such as vitamin C, vitamin E, carotenoids, and polyphenols) can help reduce such damage, theoretically supporting mitochondrial health.

However, evidence for the direct effect of proprietary vegetable and fruit blends on mitochondrial function in humans is limited. While in vitro and animal studies suggest that phytonutrients can upregulate mitochondrial biogenesis and protect against mitochondrial dysfunction, robust clinical trials in humans are lacking. Most evidence is extrapolated from general health benefits of fruit and vegetable consumption rather than specific studies on proprietary blends. Some small studies have shown improved markers of oxidative stress or energy metabolism after supplementation with concentrated fruit and vegetable extracts, but these are not definitive.

In summary, while there is a scientific rationale and some preliminary evidence, direct validation in clinical settings for proprietary vegetable and fruit blends supporting mitochondrial function remains modest. The evidence is suggestive but not strong, warranting a rating of 2 on the scale.