Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trans-geranylgeraniol is a naturally occurring diterpene alcohol involved in the biosynthesis of various biomolecules, including coenzyme Q10 (ubiquinone), which is essential for mitochondrial electron transport and ATP production. There is a growing body of preclinical evidence suggesting that geranylgeraniol and related compounds may play a role in supporting mitochondrial function. Specifically, studies in cell cultures and animal models have shown that geranylgeraniol supplementation can restore deficits in coenzyme Q10 biosynthesis, particularly in the context of statin-induced mitochondrial dysfunction, as statins inhibit the mevalonate pathway, reducing both cholesterol and coenzyme Q10 levels. Despite these promising findings, direct clinical evidence in humans demonstrating that trans-geranylgeraniol supplementation improves mitochondrial health or function is limited. Most of the data are indirect or based on mechanistic studies rather than robust clinical trials. Geranylgeraniol is not widely recognized in traditional medicine systems for mitochondrial support, and its use in dietary supplements is primarily justified by its biochemical role in cellular energy production pathways. Therefore, while there is a scientific rationale and some preclinical support for its use in mitochondrial health, the overall level of evidence is still preliminary, and more clinical research is needed to confirm efficacy and safety in humans.

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