Evidence supporting the use of: Thiamin (vitamin B1)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Thiamin (vitamin B1) is scientifically recognized as essential for mitochondrial function due to its role as a cofactor for several enzymes involved in cellular energy metabolism. Specifically, thiamin pyrophosphate (TPP), the active form of thiamin, is crucial for the activity of pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes—key enzymes in the citric acid (Krebs) cycle within mitochondria. These enzymes facilitate the conversion of carbohydrates into ATP, the main energy currency of the cell.
Deficiency in thiamin impairs mitochondrial oxidative metabolism, leading to decreased ATP production and increased oxidative stress. Clinical conditions such as beriberi and Wernicke-Korsakoff syndrome, both resulting from thiamin deficiency, demonstrate the consequences of impaired mitochondrial energy metabolism, especially in tissues with high energy demands like the heart and nervous system.
While routine thiamin supplementation in healthy individuals is not shown to enhance mitochondrial function beyond normal, evidence from studies in deficiency states and some preclinical models supports the necessity of thiamin for optimal mitochondrial health. Thus, its use for supporting the mitochondria is scientifically justified, primarily as an essential nutrient rather than as a targeted supplement for mitochondrial enhancement in the absence of deficiency.
Other ingredients that support Mitochondria
7-Keto-DHEAAcetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
L-taurine
Lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
Moringa
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic compounds
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
Rhodiola
riboflavin (vitamin B2)
rosemary
Schisandra chinensis
selenium
black ginger
spinach
strawberry
succinic acid
sulforaphane glucosinolate
Thiamin (vitamin B1)
tocotrienols
Trans-geranylgeraniol
Trans-pterostilbene
tributyrin
Turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
Water
Watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
Algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
apigenin
alpha-lipoic acid
ampelopsin
Adenosine triphosphate (ATP)
animal protein
beta-hydroxybutyrate
Beef liver
berry
caffeic Acid
centrophenoxine
Camellia sinensis
cardarine
cocarboxylase
capsinoids
Coenzyme A
cardiolipin
cyanidin
capsiate
chocolate
creatine
C-phycocyanin
dihydrolipoic acid
D-Ribose
eriocitrin
ergothioneine
flavin mononucleotide
fish
fatty acids
fungus
fucoxanthin
flavones
Ginsenosides
gamma-glutamylcysteine
glucose
Glutathione
guanidinopropionic acid (GPA )
geranylgeraniol
Haematococcus pluvialis
Honokiol
inosine
Idebenone
Kaempferol
Kaempferide
ketone salts
lipids
Methoxy-substituted benzoquinones
Myricetin
Methylxanthine
Marine fat
Mushroom
NADH
Naringenin
Nobiletin
Nannochloropsis
oxaloacetic acid
Oleoyl-phosphatidylethanolamine
oxidase
Phosphocreatine
pyrroloquinoline quinone
Phosphatidylethanolamine
paraxanthine
Phytoplankton
Polydatin
Propionyl-L-Carnitine
pyruvate
quinone
rosavins
Ribose-l-cysteine
Rosarin
ribose
Selenocysteine
Salidroside
Schisandrins
Shilajit
Stilbenoid
Sulforaphane
Tetradecylthioacetic acid
Taxifolin
Triacetyluridine
Uridine
Withanolides
Other body systems supported by Thiamin (vitamin B1)
BrainCirculatory System
Digestive System
Gastrointestinal Tract
Heart
Mitochondria
Nerves
Products containing Thiamin (vitamin B1)
Nature's Sunshine Love and Peas (Sugar Free Original Formula)
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AnxiousLess
Nature's Sunshine AnxiousLess
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cellular Energy
Nature's Sunshine Glandular System
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas (Sugar Free) NEW!
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens Pouch
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal Chocolate
Nature's Sunshine Power Meal Vanilla
Nature's Sunshine Silver Shield BioGuard Hand & Body Cream
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine B-Complex
Nature's Sunshine VitaWave
