Evidence supporting the use of: Thiamin (vitamin B1)
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Thiamin (vitamin B1) is scientifically recognized as essential for mitochondrial function due to its role as a cofactor for several enzymes involved in cellular energy metabolism. Specifically, thiamin pyrophosphate (TPP), the active form of thiamin, is crucial for the activity of pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes—key enzymes in the citric acid (Krebs) cycle within mitochondria. These enzymes facilitate the conversion of carbohydrates into ATP, the main energy currency of the cell.

Deficiency in thiamin impairs mitochondrial oxidative metabolism, leading to decreased ATP production and increased oxidative stress. Clinical conditions such as beriberi and Wernicke-Korsakoff syndrome, both resulting from thiamin deficiency, demonstrate the consequences of impaired mitochondrial energy metabolism, especially in tissues with high energy demands like the heart and nervous system.

While routine thiamin supplementation in healthy individuals is not shown to enhance mitochondrial function beyond normal, evidence from studies in deficiency states and some preclinical models supports the necessity of thiamin for optimal mitochondrial health. Thus, its use for supporting the mitochondria is scientifically justified, primarily as an essential nutrient rather than as a targeted supplement for mitochondrial enhancement in the absence of deficiency.

More about Thiamin (vitamin B1)
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