Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Stilbenoids are a class of polyphenolic compounds that include well-known molecules such as resveratrol, pterostilbene, and others. There is a growing body of preclinical (cell and animal) research indicating that certain stilbenoids, especially resveratrol, can positively influence mitochondrial function. Mechanisms proposed include activation of SIRT1 and PGC-1α, enhancement of mitochondrial biogenesis, and protection against oxidative stress. Some studies show that resveratrol improves mitochondrial efficiency and dynamics, and may attenuate mitochondrial dysfunction associated with aging and metabolic diseases. However, the majority of these findings come from animal models or in vitro systems. Human clinical trials are limited and results are mixed, often confounded by issues such as poor bioavailability and dosing. While there is some justification for using stilbenoids to support mitochondrial health, especially based on mechanistic studies, robust clinical validation in humans remains lacking. Thus, the scientific evidence for general use to support the mitochondria is moderate but not conclusive, and primarily driven by data from resveratrol rather than all stilbenoids as a class.

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