Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Schisandrins are bioactive lignans found in the fruit of Schisandra chinensis, a plant used in traditional Chinese medicine. Recent scientific research has provided evidence that Schisandrins can support mitochondrial function. Preclinical studies—primarily in vitro (cell culture) and animal models—demonstrate that Schisandrins, particularly Schisandrin B, enhance mitochondrial biogenesis, improve mitochondrial respiratory function, and protect against oxidative stress-induced mitochondrial damage. Mechanistic studies suggest Schisandrins may activate signaling pathways such as Nrf2 and PGC-1α, which are vital for mitochondrial health and cellular antioxidant defenses.

For example, in rodent models, Schisandrin B has been shown to increase ATP production, reduce mitochondrial membrane potential loss, and decrease markers of oxidative stress. Additionally, Schisandrins have demonstrated the capacity to protect mitochondria from toxin-induced injury and to support energy metabolism in various cell types. However, most evidence to date comes from laboratory and animal studies, with few clinical trials in humans directly assessing mitochondrial outcomes. Therefore, while there is a growing body of scientific evidence supporting the use of Schisandrins for mitochondrial support, more high-quality clinical research is needed to confirm these effects in humans.

References: - Szeto, YT. et al. (2011). Schisandrin B enhances mitochondrial glutathione antioxidant status in H9c2 cells and rat hearts. Biochimica et Biophysica Acta. - Panossian, A. & Wikman, G. (2008). Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. Journal of Ethnopharmacology.

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