Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ribose-l-cysteine is a synthetic compound designed to increase the body's production of glutathione, a potent intracellular antioxidant. Mitochondria are particularly susceptible to oxidative stress due to their role in cellular energy production and the resulting generation of reactive oxygen species (ROS). There is scientific interest in supporting mitochondrial function by increasing glutathione levels, as glutathione helps to neutralize ROS and protect mitochondrial integrity. Some preclinical studies (cell culture and animal models) have shown that Ribose-l-cysteine supplementation can elevate glutathione levels more effectively than some other cysteine sources, such as N-acetylcysteine, with fewer gastrointestinal side effects. Elevated glutathione in turn has been associated with improved mitochondrial function and reduced oxidative damage in these studies. However, there is a lack of large, well-controlled human clinical trials specifically investigating Ribose-l-cysteine’s effects on mitochondrial function or related health outcomes in humans. As a result, while the theoretical rationale and some preliminary studies support its use, the overall level of scientific evidence is limited at this time. More research, especially in human populations, is needed to firmly establish its efficacy for supporting mitochondrial health.

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