Evidence supporting the use of: Riboflavin (vitamin B2)
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Riboflavin (vitamin B2) is scientifically validated as an important nutrient for mitochondrial function. Riboflavin is a precursor for the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential for numerous enzymatic reactions within the mitochondria, particularly those involved in the electron transport chain and oxidative phosphorylation. These processes are crucial for cellular energy production (ATP synthesis). Deficiency in riboflavin impairs mitochondrial energy metabolism, leading to symptoms such as fatigue, muscle weakness, and, in severe cases, neurological disturbances.

There is clinical evidence supporting the use of riboflavin in disorders characterized by mitochondrial dysfunction. For example, riboflavin supplementation has shown benefit in certain inborn errors of metabolism, such as multiple acyl-CoA dehydrogenase deficiency (MADD) and some forms of mitochondrial complex I deficiency, where it can improve biochemical and clinical outcomes. Additionally, riboflavin is sometimes used as a preventive therapy for migraine headaches, a condition in which mitochondrial dysfunction has been implicated.

Overall, riboflavin’s role in supporting the mitochondrial body system is well established biochemically and supported by clinical evidence in both deficiency states and mitochondrial disorders, justifying its use for mitochondrial support.

More about riboflavin (vitamin B2)
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