Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Riboflavin (vitamin B2) has a scientifically validated role in supporting mitochondrial function. Riboflavin is a precursor for the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential components of various mitochondrial enzymes, particularly those involved in the electron transport chain and energy (ATP) production. Deficiency of riboflavin impairs mitochondrial oxidative phosphorylation and can lead to reduced cellular energy output. Clinical studies and biochemical research have demonstrated that riboflavin supplementation can improve mitochondrial function, especially in individuals with genetic mitochondrial disorders such as multiple acyl-CoA dehydrogenase deficiency (MADD) and certain complex I deficiencies. In addition, riboflavin has been used as a supportive therapy in mitochondrial diseases and is included in mitochondrial "cocktail" regimens for patients with these rare disorders. While evidence in healthy individuals is less robust, the fundamental requirement of riboflavin for mitochondrial enzyme activity is well-established. Thus, its use for supporting the mitochondrial body system is supported by biochemical and clinical evidence, especially in deficiency states or specific mitochondrial pathologies.

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