Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Potassium Alpha-Ketoglutarate (AKG) is a molecule involved in the Krebs cycle, a central metabolic pathway in mitochondria responsible for cellular energy (ATP) production. Its use to support mitochondrial function is primarily based on its biochemical role as an intermediate in this cycle. Preclinical studies, particularly in animals and in vitro, suggest that supplemental AKG can enhance mitochondrial metabolism, reduce age-related decline in mitochondrial function, and improve cellular energy efficiency. For example, supplementation has been shown to extend lifespan and healthspan in model organisms such as mice and worms, potentially through mechanisms involving improved mitochondrial function and reduced oxidative stress.

However, direct clinical evidence in humans for AKG supplementation specifically supporting mitochondrial health is limited. Some small human studies have explored AKG’s effects in contexts such as athletic performance and recovery, but these do not directly establish improved mitochondrial function. The evidence is promising but not robust; most support comes from mechanistic reasoning and preclinical data rather than large, well-controlled human trials.

In summary, while there is a scientific rationale and preliminary evidence for Potassium Alpha-Ketoglutarate supporting mitochondrial function, the quality and quantity of direct human evidence are currently limited. Further research is needed to conclusively determine its efficacy in supporting the mitochondrial body system in humans.

More about Potassium Alpha-Ketoglutarate
More about Mitochondria

Other ingredients that support Mitochondria

Other body systems supported by Potassium Alpha-Ketoglutarate

Products containing Potassium Alpha-Ketoglutarate