Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyamines such as spermidine and spermine are organic compounds found in all living cells, and recent scientific research has illuminated their role in maintaining mitochondrial function. Polyamines are involved in critical cellular processes such as DNA stabilization, gene expression, and autophagy. Specifically, spermidine has been shown to promote mitochondrial health by inducing autophagy, including mitophagy—the selective removal of damaged mitochondria. Several preclinical studies, including those in model organisms like yeast, mice, and flies, have demonstrated that supplementation with spermidine can enhance mitochondrial respiration, reduce oxidative stress, and extend lifespan, partly through improved mitochondrial quality control.

Human evidence is still emerging and primarily consists of epidemiological studies and early clinical investigations. A 2021 review in Nature Aging highlights the potential of polyamines to improve mitochondrial function and cellular health, though it also notes that most evidence is preclinical. Furthermore, dietary polyamine intake has been associated with improved metabolic markers and reduced age-related decline in some studies.

In summary, while polyamines are not traditionally used for mitochondrial support in folk medicine, scientific studies provide a moderate level of evidence (rating: 3/5) that supplementation can support mitochondrial health, mainly through autophagy and antioxidative mechanisms. Clinical validation in humans is ongoing, but mechanistic and animal studies provide a credible scientific basis for their use in this context.

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