Phenolic acids, a group of phytochemicals found abundantly in fruits, vegetables, coffee, and whole grains, have been studied for their antioxidant properties and their role in supporting mitochondrial health. The scientific rationale for their use is based on both in vitro and animal studies, which indicate that phenolic acids such as caffeic acid, ferulic acid, and gallic acid can help protect mitochondria from oxidative damage by scavenging free radicals and improving endogenous antioxidant defenses. Some studies have demonstrated that phenolic acids can enhance mitochondrial biogenesis, increase ATP production, and reduce mitochondrial dysfunction, particularly in models of neurodegenerative diseases and metabolic disorders.

However, the body of evidence in humans is still limited. While cell culture and animal models provide promising data, clinical trials directly linking phenolic acid supplementation to improved mitochondrial function in humans are sparse. Most available human studies are indirect, showing benefits in oxidative stress markers and metabolic health, which may be partially mediated by improved mitochondrial activity. Therefore, while scientific interest and mechanistic plausibility exist, the evidence supporting the use of phenolic acids specifically for mitochondrial health in humans is moderate but not yet robust or conclusive.