Evidence supporting the use of: Pantothenic acid (vitamin B5)
For the body system: Mitochondria

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pantothenic acid (vitamin B5) is essential for the synthesis of coenzyme A (CoA), a critical cofactor in mitochondrial energy metabolism. CoA is required for the Krebs cycle (also known as the citric acid or TCA cycle), which occurs within the mitochondria and is fundamental to cellular energy production via ATP synthesis. Deficiency in pantothenic acid can impair CoA production, potentially disrupting mitochondrial function. However, in healthy individuals with adequate dietary intake, pantothenic acid deficiency is rare. Most scientific studies confirm its indispensability in basic mitochondrial function, rather than demonstrating improved mitochondrial performance or energy levels with supplementation above the recommended dietary allowance.

There is little robust clinical evidence supporting the use of pantothenic acid supplementation to enhance mitochondrial health or function in individuals without a deficiency. The majority of evidence comes from animal studies and biochemical knowledge, not from clinical trials in humans targeting mitochondrial disorders or dysfunction. Thus, while pantothenic acid is biochemically required for mitochondrial energy metabolism, there is only limited scientific support for using it as a supplement specifically to "support the mitochondrial body system" in people who are not deficient.

References:

  • Leonardi, R., & Jackowski, S. (2007). "Biosynthesis and Regulation of Coenzyme A". Journal of Biological Chemistry, 282(23), 17340–17344.
  • National Institutes of Health Office of Dietary Supplements. "Pantothenic Acid Fact Sheet for Health Professionals".

More about pantothenic acid (vitamin B5)
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
L-carnosine
L-citrulline
L-glutathione
L-glycine
L-taurine
Lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
Moringa
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic compounds
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
Rhodiola
riboflavin (vitamin B2)
rosemary
Schisandra chinensis
selenium
black ginger
spinach
strawberry
succinic acid
sulforaphane glucosinolate
Thiamin (vitamin B1)
tocotrienols
Trans-geranylgeraniol
Trans-pterostilbene
tributyrin
Turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
Water
Watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
Algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
apigenin
alpha-lipoic acid
ampelopsin
Adenosine triphosphate (ATP)
animal protein
beta-hydroxybutyrate
Beef liver
berry
caffeic Acid
centrophenoxine
Camellia sinensis
cardarine
cocarboxylase
capsinoids
Coenzyme A
cardiolipin
cyanidin
capsiate
chocolate
creatine
C-phycocyanin
dihydrolipoic acid
D-Ribose
eriocitrin
ergothioneine
flavin mononucleotide
fish
fatty acids
fungus
fucoxanthin
flavones
Ginsenosides
gamma-glutamylcysteine
glucose
Glutathione
guanidinopropionic acid (GPA )
geranylgeraniol
Haematococcus pluvialis
Honokiol
inosine
Idebenone
Kaempferol
Kaempferide
ketone salts
lipids
Methoxy-substituted benzoquinones
Myricetin
Methylxanthine
Marine fat
Mushroom
NADH
Naringenin
Nobiletin
Nannochloropsis
oxaloacetic acid
Oleoyl-phosphatidylethanolamine
oxidase
Phosphocreatine
pyrroloquinoline quinone
Phosphatidylethanolamine
paraxanthine
Phytoplankton
Polydatin
Propionyl-L-Carnitine
pyruvate
quinone
rosavins
Ribose-l-cysteine
Rosarin
ribose
Selenocysteine
Salidroside
Schisandrins
Shilajit
Stilbenoid
Sulforaphane
Tetradecylthioacetic acid
Taxifolin
Triacetyluridine
Uridine
Withanolides

Other body systems supported by pantothenic acid (vitamin B5)

Adrenal Cortex
Adrenal Glands
Brain
Cortisol
Glandular System
Hair
Mitochondria
Nerves
Skin