Oleanolic acid is a natural triterpenoid compound found in many plants, including olives and various herbs. Its potential role in supporting mitochondrial function has attracted some scientific interest. Preclinical studies, particularly in vitro and in animal models, suggest that oleanolic acid may exert protective effects on mitochondria. These effects include reducing mitochondrial oxidative stress, enhancing mitochondrial biogenesis (the process by which new mitochondria are formed), and improving mitochondrial function in the context of various metabolic and neurodegenerative disease models.

The mechanisms proposed for these effects involve the modulation of antioxidant pathways (such as Nrf2 activation), anti-inflammatory actions, and possible regulation of key enzymes and signaling pathways involved in mitochondrial health. For example, some studies have shown that oleanolic acid can protect neuronal cells from mitochondrial dysfunction induced by toxins or high-fat diets by improving mitochondrial membrane potential and reducing reactive oxygen species (ROS) production.

However, it is important to note that while these preclinical findings are promising, there is a lack of robust clinical evidence in humans to confirm oleanolic acid’s efficacy for supporting mitochondrial function. No large-scale, well-controlled human trials have established its benefits for this specific purpose. Thus, while there is some scientific rationale and early evidence, the overall rating for evidence remains low pending further research.