Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Nicotinamide Mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in mitochondrial energy metabolism. The scientific rationale for NMN supplementation to support mitochondrial function is based on its role in boosting NAD+ levels, which decline with age and metabolic stress. Preclinical studies in animals have shown that NMN supplementation can restore NAD+ concentrations, enhance mitochondrial function, and improve markers of metabolic health and energy production. For example, mouse studies have demonstrated improved mitochondrial biogenesis and physical endurance after NMN administration. In addition, NMN has been found to activate sirtuins, a family of proteins that regulate mitochondrial health and cellular energy. However, human clinical research is still in the early stages. Recent small-scale trials have shown that NMN is safe and can increase NAD+ levels in blood, but conclusive evidence for direct improvements in mitochondrial function or clinical outcomes in humans is limited. Still, the mechanistic basis and promising animal data provide moderate scientific support for NMN’s proposed benefits to the mitochondrial system. Larger, more definitive human trials are needed to fully validate these effects.

More about Nicotinamide Mononucleotide
More about Mitochondria

Other ingredients that support Mitochondria

Other body systems supported by Nicotinamide Mononucleotide

Products containing Nicotinamide Mononucleotide