Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Nicotinamide Adenine Dinucleotide (NAD⁺) is a critical coenzyme found in all living cells, playing a central role in cellular metabolism and mitochondrial function. The mitochondria are often referred to as the "powerhouses" of the cell, as they generate adenosine triphosphate (ATP), the primary energy currency. NAD⁺ is essential for redox reactions in the mitochondrial electron transport chain, which is fundamental for ATP production. Scientific evidence supports the idea that maintaining or boosting NAD⁺ levels can improve mitochondrial function.

Numerous animal studies and some human clinical trials have shown that precursors of NAD⁺ (such as nicotinamide riboside and nicotinamide mononucleotide) enhance NAD⁺ levels and positively affect mitochondrial health, energy metabolism, and may slow aspects of aging. For example, NAD⁺ supplementation has been linked to improved mitochondrial biogenesis, enhanced oxidative metabolism, and protection against age-related mitochondrial decline (Yoshino et al., Cell Metab, 2018). However, while preclinical data are robust, large-scale human studies are still limited, and more research is needed to confirm the benefits and optimal dosing strategies in humans.

In summary, the use of NAD⁺ to support mitochondrial function is scientifically grounded, with a strong biochemical rationale and growing empirical evidence, though clinical translation is still in progress.

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