Evidence supporting the use of: Niacin (vitamin B3)
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Niacin (vitamin B3) plays a scientifically validated role in supporting mitochondrial function. Niacin is a precursor for the coenzymes nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+), which are essential for mitochondrial energy metabolism. NAD+ is a key electron carrier in the mitochondrial electron transport chain, facilitating oxidative phosphorylation and ATP production. Deficiency of niacin impairs mitochondrial energy generation, resulting in cellular dysfunction and clinical conditions such as pellagra.

Recent research has focused on the role of NAD+ in mitochondrial health and aging. Studies in cell and animal models have shown that supplementation with niacin or related compounds can boost NAD+ levels, improve mitochondrial function, and enhance resistance to metabolic stress. In humans, clinical trials have demonstrated that niacin supplementation increases NAD+ availability, though direct evidence for long-term improvements in mitochondrial function or specific health outcomes remains limited.

Overall, the use of niacin to support mitochondrial function is grounded in established biochemistry and supported by emerging research, but high-quality clinical evidence in humans is moderate rather than definitive. Therefore, niacin is scientifically justified for mitochondrial support, with a moderate evidence rating.

More about niacin (vitamin B3)
More about Mitochondria

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