Various mushrooms, particularly species like Cordyceps, Reishi (Ganoderma lucidum), and Shiitake (Lentinula edodes), have been studied for their potential effects on mitochondrial function. Scientific interest centers on their bioactive compounds, such as polysaccharides, triterpenes, and cordycepin, which have been shown in preclinical studies to support mitochondrial health. For example, research on Cordyceps has demonstrated increased ATP production and improved mitochondrial biogenesis in animal and cell models, as well as enhanced endurance and reduced fatigue, which are suggestive of improved mitochondrial efficiency (Chen et al., 2013).

Other mushrooms, like Reishi, have demonstrated antioxidant properties that may protect mitochondria from oxidative stress (Wachtel-Galor et al., 2004). However, the majority of scientific evidence comes from in vitro or animal studies, and rigorous clinical trials in humans are limited. The traditional use of mushrooms in Asian medicine often overlaps with claims of vitality and longevity, but direct reference to "mitochondrial support" is a modern scientific concept. Accordingly, while promising preclinical evidence exists, human data are not yet robust enough to fully validate these effects.