Moringa (Moringa oleifera) has been traditionally used for a variety of health purposes, but its role in supporting mitochondrial function is based primarily on emerging scientific research rather than longstanding tradition. Preclinical studies suggest that moringa leaf extracts contain bioactive compounds such as polyphenols, flavonoids, and vitamins (notably vitamin C and E), which possess antioxidant properties. These antioxidants may help protect mitochondria from oxidative stress—a known contributor to mitochondrial dysfunction—by neutralizing reactive oxygen species (ROS).

Some animal and in vitro studies have demonstrated that moringa supplementation can enhance mitochondrial biogenesis, improve mitochondrial membrane potential, and reduce markers of oxidative stress in various tissues, including the liver and brain. For instance, a few rodent studies reported improved mitochondrial enzyme activities and reduced lipid peroxidation following moringa supplementation, suggesting a supportive effect on mitochondrial health.

However, direct clinical evidence in humans is lacking. Most data come from animal models or cell culture studies, and there are currently no robust human trials specifically evaluating moringa's effect on mitochondrial function. Therefore, while there is a scientific basis for its use rooted in preclinical data, the overall evidence supporting moringa for mitochondrial support in humans remains limited.