Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium malate is sometimes promoted for mitochondrial support due to its components: magnesium, an essential mineral involved in over 300 enzymatic reactions, and malate (malic acid), a key intermediate in the Krebs cycle (the central pathway for energy production within mitochondria). Some scientific rationale exists for this use. Magnesium is required for ATP synthesis and proper mitochondrial function. Malate participates directly in cellular energy production by shuttling electrons within the Krebs cycle. The notion is that supplying both together may support mitochondrial energy metabolism, especially in cases of deficiency or increased energy demand.

However, while animal and in vitro studies confirm the critical role of both magnesium and malate in mitochondrial biochemistry, direct clinical evidence for supplemental magnesium malate improving mitochondrial function in humans is limited. A few small studies have examined its use in conditions like fibromyalgia, where mitochondrial dysfunction has been hypothesized, but results are mixed and sample sizes are small. Thus, while there is a plausible biochemical basis and some initial research, robust clinical trials validating magnesium malate for mitochondrial support are lacking. As such, the evidence rating is moderate to low (2 out of 5).

In summary, magnesium malate’s use for mitochondrial support is grounded in biochemistry and preliminary research, but remains insufficiently validated by large-scale, high-quality clinical trials.

More about Magnesium Malate
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
Flavin mononucleotide
Fish
Fatty acids
Fucoxanthin
Flavones
Ginsenosides
Gamma-Glutamylcysteine
glucose
Glutathione
Geranylgeraniol
Ketone Salts

Other body systems supported by Magnesium Malate

Brain
Mitochondria
Muscles
Nerves
Skeletal System (Bones)

Products containing Magnesium Malate

We currently have no products on Caring Sunshine that contain this ingredient.