Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ketones, specifically exogenous ketones such as beta-hydroxybutyrate (BHB), have garnered scientific interest for their potential to support mitochondrial function. Mitochondria are the energy-producing organelles in cells, and ketones serve as an alternative fuel source, particularly during periods of low glucose availability (e.g., fasting, ketogenic diet). Several studies have shown that ketone bodies can increase mitochondrial biogenesis, improve mitochondrial efficiency, and reduce the production of reactive oxygen species (ROS) during ATP generation. These effects are thought to be mediated by the signaling properties of ketones, including influencing gene expression related to energy metabolism and antioxidant defenses.

Animal and cell culture studies indicate that ketones can enhance mitochondrial respiration and protect against mitochondrial dysfunction, which is implicated in neurological disorders and metabolic diseases. However, human evidence remains limited and mostly indirect, with some clinical trials suggesting improvements in cognitive function and endurance performance, possibly due to enhanced mitochondrial efficiency. While promising, more research is necessary to establish definitive benefits and optimal protocols for exogenous ketone supplementation in supporting the mitochondrial system in humans.

In summary, there is a growing body of scientific evidence, primarily from preclinical studies, that ketones can support mitochondrial function, but large-scale, long-term human trials are still needed to confirm these effects.

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