Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperetin is a flavonoid found primarily in citrus fruits and is a major metabolite of hesperidin. Its potential benefit for mitochondrial health is supported by a growing body of preclinical research. Several in vitro and animal studies have demonstrated that hesperetin can enhance mitochondrial biogenesis, improve mitochondrial function, and reduce mitochondrial oxidative stress. For example, studies in rodent models have shown that hesperetin treatment can increase the expression of key regulators of mitochondrial biogenesis, such as PGC-1α, NRF1, and TFAM, leading to improved mitochondrial density and function. Additionally, hesperetin exhibits antioxidant properties that can help protect mitochondria from oxidative damage, which is critical for maintaining mitochondrial integrity and energy production. However, while these findings are promising, most of the evidence is limited to cell and animal studies, with very limited direct clinical research in humans linking hesperetin supplementation to mitochondrial health outcomes. Therefore, while the mechanistic rationale and preclinical data are relatively strong, the overall evidence is still preliminary, pending more rigorous human trials.

In summary, the use of hesperetin to support mitochondrial health is based on scientific rationale and preclinical evidence, but direct clinical validation in humans is lacking, warranting a moderate evidence rating.

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