Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavanols, a subgroup of flavonoids found abundantly in foods such as cocoa, tea, apples, and berries, have been studied for their effects on mitochondrial function. Scientific research, primarily in vitro and in animal models, suggests that flavanols can support mitochondrial health by enhancing mitochondrial biogenesis, reducing oxidative stress, and improving mitochondrial efficiency. Key mechanisms involve activation of signaling pathways such as AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), both of which are central to mitochondrial biogenesis and function.

For example, studies have shown that epicatechin, a prominent flavanol in cocoa, can increase the number and function of mitochondria in skeletal muscle and cardiac tissue in rodents. Additionally, flavanols possess strong antioxidant properties, which may help mitigate mitochondrial damage caused by reactive oxygen species (ROS). Some human studies suggest improvements in vascular function and exercise performance, which could be partially attributed to enhanced mitochondrial activity, though direct evidence in humans remains limited.

Overall, while there is promising preclinical evidence supporting the role of flavanols in supporting mitochondrial health, the direct clinical evidence in humans is still emerging. The use of flavanols for mitochondrial support is therefore scientifically plausible and partially validated, but more rigorous human studies are needed to confirm these effects and establish optimal intake levels.

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