Cordycepic acid, also known as D-mannitol, is a compound isolated from the medicinal fungus Cordyceps sinensis, which has a long history of use in traditional Chinese medicine. The fungus itself has been used for centuries as a general tonic to support vitality, energy, and stamina, and it is often believed to enhance physical performance and support the body’s natural energy production, which is associated with mitochondrial function.

Historically, the use of Cordyceps and its constituents—including cordycepic acid—has been based largely on traditional knowledge rather than rigorous scientific evaluation. There are limited preclinical studies suggesting that extracts of Cordyceps may influence ATP production or mitochondrial biogenesis in cell and animal models, but these effects are generally attributed to the whole extract rather than cordycepic acid alone. Clinical studies isolating cordycepic acid’s direct effects on mitochondrial function in humans are lacking.

Therefore, while cordycepic acid is included in formulas with the intent to support energy and vitality—concepts linked to mitochondrial health—its use for this specific purpose is justified primarily by traditional practices rather than robust scientific evidence.