Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Coffee is widely consumed and contains bioactive compounds such as caffeine, polyphenols, and diterpenes. There is scientific evidence suggesting that coffee may support mitochondrial function, primarily due to its antioxidant properties and its impact on cellular metabolism. Caffeine, the most abundant psychoactive compound in coffee, has been shown in animal and in vitro studies to enhance mitochondrial biogenesis through the upregulation of PGC-1α, a key regulator of mitochondrial production and function (source). Additionally, the polyphenols in coffee, such as chlorogenic acids, have demonstrated protective effects against oxidative stress, which is a major factor in mitochondrial dysfunction (source). Human observational studies associate regular coffee consumption with a lower risk of neurodegenerative diseases, in which mitochondrial dysfunction is implicated, although causation is not established. Nevertheless, most of the direct experimental evidence comes from preclinical models, and the effects in humans are inferred rather than conclusively demonstrated. Thus, while there is a plausible scientific rationale and moderate supporting evidence for coffee’s role in supporting mitochondrial health, more targeted clinical trials are needed to fully validate these effects in humans.

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