Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Calcium Beta-Hydroxybutyrate (Ca-BHB) is a ketone salt, commonly used as an exogenous ketone supplement to elevate blood levels of beta-hydroxybutyrate (BHB), a primary ketone body. There is scientific rationale for its use in supporting mitochondrial function, albeit primarily from preclinical and mechanistic studies. BHB can serve as an alternative energy substrate for mitochondria, especially during periods of low glucose availability, such as fasting or ketogenic diets. Research indicates that BHB is efficiently metabolized in the mitochondria to generate ATP, thus supporting cellular energy production.

Moreover, BHB has been found to influence mitochondrial biogenesis and may upregulate antioxidant defenses via the activation of signaling pathways like PGC-1α and inhibition of histone deacetylases (HDACs). Animal and cell studies suggest BHB can reduce oxidative stress and improve mitochondrial efficiency. However, direct clinical trials in humans using Calcium Beta-Hydroxybutyrate specifically to enhance mitochondrial function are limited. Most human studies focus on metabolic effects, cognitive performance, or exercise capacity rather than direct mitochondrial outcomes.

In summary, there is a moderate scientific basis (evidence rating 3/5) supporting the use of Calcium Beta-Hydroxybutyrate for mitochondrial support, grounded mainly in mechanistic and preclinical research. Clinical validation in humans for this specific purpose remains limited, but the existing evidence does suggest a plausible benefit.

More about Calcium Beta-Hydroxybutyrate
More about Mitochondria

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Other body systems supported by Calcium Beta-Hydroxybutyrate

Brain
Mitochondria

Products containing Calcium Beta-Hydroxybutyrate

We currently have no products on Caring Sunshine that contain this ingredient.