Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Alpha lipoic acid (ALA) is a naturally occurring compound that plays a critical role in mitochondrial bioenergetics. It acts as a cofactor for mitochondrial enzyme complexes involved in oxidative metabolism, particularly the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes. These complexes are essential for energy production within the mitochondria, the ‘powerhouse’ of the cell. Multiple preclinical studies and some clinical research suggest that ALA can enhance mitochondrial function, reduce oxidative stress, and improve cellular energy status. ALA is a potent antioxidant, able to scavenge free radicals and regenerate other antioxidants such as vitamins C and E, further supporting mitochondrial health. Clinical trials have investigated ALA supplementation in conditions linked to mitochondrial dysfunction such as diabetic neuropathy, and some studies have shown improvements in symptoms and markers of oxidative stress. However, while there is promising evidence for ALA’s role in supporting mitochondrial function, especially in disease states, large-scale, long-term clinical trials in healthy individuals are limited. Thus, its use is scientifically justified, with a moderate to strong evidence base (4/5), primarily due to its well-characterized biochemical role and supportive, though not definitive, clinical data.

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Products containing alpha lipoic acid

Nature's Sunshine Alpha Lipoic Acid
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Nature's Sunshine Cellular Energy
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Nature's Sunshine Super Antioxidant
Nature's Sunshine VitaWave