Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Adenosine triphosphate (ATP) is the primary energy currency of the cell and is fundamentally involved in mitochondrial function. Mitochondria are often referred to as the "powerhouses" of the cell because they generate the majority of the cell’s ATP through oxidative phosphorylation. Scientific research has thoroughly validated the central role of ATP in mitochondrial bioenergetics. ATP is both produced and utilized within mitochondria to power various cellular processes, including muscle contraction, active transport across membranes, and biosynthetic reactions. Defects in mitochondrial ATP production are linked to a variety of mitochondrial diseases and metabolic disorders. Numerous peer-reviewed studies have demonstrated that ATP supplementation or precursors (such as creatine or D-ribose) can help in conditions of mitochondrial dysfunction, although direct ATP supplementation is limited by poor cellular uptake. The relationship between ATP and mitochondrial health is a foundational concept in cell biology, biochemistry, and medicine, and is detailed in countless scientific reviews and textbooks. Therefore, the use of ATP as a concept or target to support mitochondrial function is strongly backed by scientific evidence, although the effectiveness of exogenous ATP supplementation remains an area of ongoing research.

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