Evidence supporting the use of: Acetyl-L-Carnitine-L-Arginine
For the body system: Mitochondria

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Acetyl-L-Carnitine (ALCAR) and L-Arginine are both compounds that have been studied for their effects on mitochondrial function, though the strength of evidence varies between them and is generally moderate. ALCAR is a well-known mitochondrial nutrient that plays a direct role in the transport of fatty acids into the mitochondria for beta-oxidation, which is crucial for ATP production. Clinical and preclinical studies have shown that ALCAR supplementation may improve mitochondrial energy metabolism, reduce oxidative stress, and support neuronal health, particularly in neurodegenerative diseases and age-related cognitive decline. (Reference: NCBI)

L-Arginine is a semi-essential amino acid that primarily serves as a precursor to nitric oxide, a molecule that improves blood flow and may indirectly support mitochondrial function by enhancing oxygen and nutrient delivery. Some studies suggest that L-Arginine can stimulate mitochondrial biogenesis and function, but the evidence is less direct and less robust than for ALCAR. There is limited research specifically on the combined use of Acetyl-L-Carnitine and L-Arginine for mitochondrial support, though some synergistic effects may exist.

In summary, there is moderate scientific support (rating 3/5) for the use of Acetyl-L-Carnitine in supporting mitochondrial function, while L-Arginine's effects are more indirect. More large-scale, controlled studies are needed to confirm their efficacy, especially in combination.

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Products containing Acetyl-L-Carnitine-L-Arginine

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