Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, also known as folate or folic acid (when used in supplements and fortified foods), is scientifically validated for use in pregnancy, primarily to prevent neural tube defects in the developing fetus. While its direct role in miscarriage prevention is less clear, low folate status has been associated with an increased risk of miscarriage in some observational studies. Folate is crucial for DNA synthesis, repair, and methylation, processes essential in early embryonic development. Deficiencies have been linked to problems in cell division and placental development, theoretically increasing miscarriage risk.

Randomized controlled trials specifically evaluating folic acid supplementation for miscarriage prevention have produced inconsistent results, and systematic reviews note insufficient evidence for a definitive protective effect against miscarriage. However, guidelines from major health organizations, such as the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC), strongly recommend folic acid supplementation for women of reproductive age, largely for neural tube defect prevention. This widespread use may contribute indirectly to lower miscarriage risk due to improved overall pregnancy outcomes.

In summary, the use of Vitamin B9 for miscarriage prevention is supported by some scientific evidence, mostly observational, and is justified due to its established benefits for pregnancy health, although direct evidence for miscarriage prevention is moderate rather than strong.

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