Evidence supporting the use of: Vitamin D3
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 has been investigated as a potential adjunct in the management of migraine, and there is emerging but limited scientific evidence to support its use. Several observational studies have found an association between low vitamin D levels and increased prevalence or severity of migraine. Some small randomized controlled trials (RCTs) have suggested that vitamin D supplementation may reduce the frequency and severity of migraine attacks, particularly in individuals with vitamin D deficiency. For example, a 2019 double-blind RCT published in Headache found that daily supplementation with 2,000 IU of vitamin D3 for 24 weeks resulted in a significant reduction in headache frequency compared to placebo, especially in patients who had low baseline levels of vitamin D. Proposed mechanisms include vitamin D’s anti-inflammatory properties, its role in modulating neuronal excitability, and its effects on neurotransmitter regulation.

However, the current body of evidence is still limited by small sample sizes, short follow-up periods, and heterogeneity in dosage and patient populations. Not all studies have found a significant benefit, and there is no consensus on optimal dosing or specific patient groups who might benefit most. Most clinical guidelines do not currently recommend vitamin D3 as a standard treatment for migraine, though it may be considered in patients with documented deficiency. In summary, while there is some scientific basis for the use of vitamin D3 in migraine prevention, the overall evidence is preliminary and further large-scale, high-quality studies are needed.

More about vitamin D3
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Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone