Evidence supporting the use of: Vitamin B6 (pyridoxine 5-phosphate)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (in its active form, pyridoxal 5-phosphate) has some scientific evidence supporting its use in migraine management, though the evidence is limited and not conclusive. B6 is involved in neurotransmitter synthesis, including serotonin, which is implicated in migraine pathophysiology. Several small clinical studies and trials have investigated Vitamin B6, often in combination with other B vitamins (such as folic acid and B12), for migraine prophylaxis. A few studies, particularly those targeting individuals with elevated homocysteine levels (sometimes due to MTHFR gene mutations), have shown that B6 supplementation can reduce migraine frequency and severity. For example, a randomized controlled trial published in 2015 found that a combination of B6, B9 (folic acid), and B12 reduced migraine disability in patients with migraine with aura, likely through lowering homocysteine levels. However, Vitamin B6 alone has not been extensively studied for migraine, and most clinical trials combine B6 with other nutrients. Systematic reviews recognize the potential benefit but generally rate the evidence as low to moderate quality due to small sample sizes and methodological limitations. Thus, while there is some scientific rationale and preliminary data, Vitamin B6 should not be considered a primary standalone therapy for migraine, and more robust clinical trials are needed to establish its efficacy.

More about Vitamin B6 (pyridoxine 5-phosphate)
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Vitamin B6 (pyridoxine 5-phosphate)

We currently have no products on Caring Sunshine that contain this ingredient.