Evidence supporting the use of: Vitamin B6 (Mixed)
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its potential role in the management of migraine, particularly migraine with aura. The justification for its use is based primarily on scientific research rather than longstanding tradition. Several studies have explored the relationship between homocysteine metabolism and migraine, as elevated homocysteine levels have been implicated in migraine pathophysiology. Vitamin B6, along with folic acid and vitamin B12, is involved in the metabolism of homocysteine. A few small clinical trials have examined the effect of vitamin B6, often in combination with folic acid and B12, on migraine frequency and severity. For example, a randomized controlled trial published in Pharmacogenetics and Genomics (2009) found that supplementation with these vitamins reduced migraine disability, frequency, and severity in women with migraine with aura. However, the evidence is not robust, as many studies have small sample sizes, and the benefit appears more pronounced in specific subpopulations (e.g., those with elevated homocysteine or genetic variants affecting homocysteine metabolism). Overall, while scientific interest exists and preliminary studies suggest a possible benefit, the evidence base is limited and not sufficient for strong clinical recommendations. Larger and more rigorous trials are needed to determine the extent of vitamin B6's efficacy in migraine management.

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